Why the sudden freak out over TPO? European regulators labeled it “carcinogenic, mutagenic, or toxic to reproduction.” That sounds terrifying, but the research is still in the early stages. Most of the concern comes from animal studies linking TPO to fertility issues and potential harm to reproductive organs.
trimethylbenzoyl diphenylphosphine oxide
What an odd abbreviation
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From the wikipedia article: https://en.wikipedia.org/wiki/Phosphine
Phosphine - Phosphine (IUPAC name: phosphane) is a colorless, flammable, highly toxic compound.
Phosphine is used for pest control, but its usage is strictly regulated due to high toxicity.[40][41] Gas from phosphine has high mortality rate[42] and has caused deaths in Sweden and other countries.[43][44][45]
All of those other letters around “phosphine” in “Trimethylbenzoyl Diphenylphosphine Oxide” are important too. You can’t really just pull out one part of a chemical name like that and pretend like that tells you much about the properties of that substance.
Like how “sodium chloride” is neither a poisonous gas like chlorine, nor a highly reactive metal like sodium, but is in fact ordinary table salt.
Or methane, methamphetamine, methadone, methanol, methyl anthranilate, etc… all very different chemicals that happen to have a methyl group as part of their structure (3 hydrogen atoms bonded to one carbon atom)
I’m not saying that TPO is safe, it’s just that the fact that “phosphine” appears in the chemical name doesn’t mean all that much in the way that you’re trying to imply.
For anyone who’s into this sort of thing, NileRed on YouTube does a lot of stuff where he’ll, for example, show how part of the structure of a chemical found in, for example, rubber gloves, is also found in a totally different chemical, like the one that makes chili peppers spicy, then takes a bunch of rubber gloves, extracts that chemical from them, does some chemistry stuff to turn it into the spicy chemical and makes hot sauce with it.
Chemically they’re not that similar. I wouldn’t draw the conclusion there’s any relation.
Do you have anything to offer regarding TPO, then? You appear to have a high opinion of your knowledge of the topic, so please share.
Here’s what I’ve found using DDG: https://www.cir-safety.org/sites/default/files/SLR_TrimethylbenzoylDiphenylphosphineOxide_122024.pdf Pages 6-9 Include: “Some of the adverse effects observed in this study include body weight reduction, abnormalities in clinical chemistry, increased liver, kidney, brain, adrenal gland, and testes weight, and marked diffuse atrophy of the testicular parenchyma (compared to controls; these effects were observed in the mid- and high-dose groups). Testicular atrophy, decreased mean testes weight, and decreased mean body weights (compared to controls) were also observed in a different 90-d assay performed in male Wistar rats (10/group) given Trimethylbenzoyl Diphenylphosphine Oxide (purity 99.3%; 1000 mg/kg bw/d) in a 0.5% carboxymethylcellulose aqueous solution via gavage”
I mean from what that study describes there might be some toxic properties at high-ish doses: the 60mg/kg/day showed no effects. That would mean 3.6g for a 60kg human sized rat taken orally, which is quite a lot to accidentally eat. I think the limit is 5% TPO in the nail products, so you’d have to be trying to ingest it.
But my original comment is that I don’t think there’s much relation with phosphine.
TIL Vice News is back… again.
