The first line of Shirley Jackson’s Haunting Of Hill House is a banger, the complete first paragraph is incredible.

No live organism can continue for long to exist sanely under conditions of absolute reality; even larks and katydids are supposed, by some, to dream. Hill House, not sane, stood by itself against its hills, holding darkness within; it had stood so for eighty years and might stand for eighty more. Within, walls continued upright, bricks met nearly, floors were firm, and doors were sensibly shut; silence lay steadily against the wood and stone of Hill House, and whatever walked there, walked alone

Some art pieces change the way you see the world by opening your eyes to new perspectives, others do it by inflicting acute trauma to the occipital lobe.

Blade Runner’s a bit different since the replicants are flesh and blood, just not naturally born.